Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
نویسندگان
چکیده
منابع مشابه
Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity
PURPOSE To investigate the role of parkin in regulating mitochondrial homeostasis of retinal ganglion cells (RGCs) under glutamate excitotoxicity. METHODS Rat RGCs were purified from dissociated retinal tissue with a modified two-step panning protocol. Cultured RGCs were transfected with parkin using an adenovirus system. The distribution and morphology of mitochondria in the RGCs were assess...
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AIM To study the effects of KN-62, an inhibitor of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II), on the damage of cortical neurons and mechanisms of the loss of CCDPK II activity induced by sodium glutamate (Glu). METHODS CCDPK II activity was measured by 32P incorporation and backphosphorylations of endogenous proteins were studied by autoradiography. RESULTS 1) KN-62 provided ...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2019
ISSN: 1662-453X
DOI: 10.3389/fnins.2019.01027